Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

Are you passionate about developing next-gen CRISPR therapies? We are seeking a highly motivated and creative Scientist to grow our diverse, innovation-focused CRISPR-X team that pioneers novel gene editing therapies for human disease. We are part of CRISPR Therapeutics, a leading gene editing company with a broad clinical portfolio, and research sites in Boston and San Francisco. The successful candidate will be an integral part of our team, whose aim is to research, develop and advance the next generation of genome editing modalities and genetic therapies for a wide range of human indications. The position requires enthusiasm, passion, outstanding skills in the art, attention to detail, and a desire to create new medicines for patients.

Responsibilities

• Design, execute, and optimize research with the aims of exploring and developing next-generation editing technologies for gene correction and gene insertion.
• Analyze and present experimental data to a wide range of audiences
• Dissect published literature to find novel solutions to gene editing challenges
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.

Minimum Qualifications

• Expertise in the design and construction of nucleic acids for expression in human cells, using modern molecular biology techniques including Gibson cloning, golden gate cloning, PCR, gel electrophoresis, bacterial transformation, and sequencing
• Expertise in mammalian cell culture, high-throughput cellular assays, and diverse nucleic acid delivery methods (e.g. lipofection, nucleofection, lipid nanoparticles, viral vectors)
• Expertise in standard cell and molecular biology assays, including next generation sequencing, qPCR/ddPCR, flow cytometry, microscopy, and protein assays
• Expertise in CRISPR and gene editing concepts
• Expertise in experimental design and data analysis, especially with regard to gene editing outcomes
• Ph.D. in biology, bioengineering, or related discipline.
• 0-3 years of relevant experience focused on gene editing technologies.
• Academic and/or industry experience in the field with track record demonstrating significant contributions
• Outstanding problem-solving skills and attitude to think outside the box
• Excellent writing, reviewing, and presentation skills
• Track record of intellectually challenging oneself to enhance scientific capabilities
• Ability to work independently as well as collaboratively in a results-oriented research team environment
• Must possess critical thinking and self-reliance to solve tasks independently
• Self-motivated and scientifically rigorous, with outstanding organization and multitasking capability
• Entrepreneurial spirit showing resourcefulness, accountability, agility to pivot, transparency, and productivity

Preferred Qualifications

• Prior experience with protein and/or RNA engineering
• Prior experience with library generation and high-throughput screening
• Prior experience with mRNA design and lipid nanoparticles
• Prior experience with primary cells including primary human hepatocytes
• Prior experience in computational biology
• Knowledge of in vivo experiments

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

Minimum base salary of $122,000 to a maximum base salary of $138,000 + discretionary bonus, equity and benefits.

The range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities. Consult with your recruiter to determine a more targeted range based on these job-related factors.

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy

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