Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

CRISPR Therapeutics is seeking a Senior/ Principal Research Associate to join the team and support the development of novel formulations that would reach far beyond the liver in support of the in vivo and immuno-oncology programs. A successful candidates should have a good understanding of nanoparticle formulations and downstream purification combined with some basic experience in the space of synthesis and characterization of small molecules/materials. The position requires enthusiasm, passion, attention to detail and a desire to join a growing team to build formulation at LNP at CRISPR Therapeutics.

Responsibilities

• Assist in the synthesis, characterization and formulation of novel lipid chemistries and their incorporation in LNP systems.
• Analyze LNP critical quality attributes such as size, encapsulation efficiency, zeta potential, etc.
• Design and execute experiments to optimize LNP compositions.
• Formulate different nucleic acid payloads to support company’s in vivo and immuno-oncology programs.
• Maintain thorough and detailed electronic lab notebooks and documentation records.
• Analyze, interpret, and summarize experimental data.
• Communicate results to team members through written technical reports or oral presentations.
• Adhere to all laboratory safety requirements and procedures.
• Assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies.

Minimum Qualifications

• BS/MS in Chemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences or related discipline
• Industry Experience
  • Senior Research Associate – 4-7 years or 2-5 years with advanced degree
  • Principal Research Associate – 6-10 years or 4-8 years with advanced degree
• Knowledge of process scale up/scale down
• Excellent oral and written communication skills
• Track record of intellectually challenging oneself to enhance scientific capabilities
• Ability to work independently as well as part of a results-oriented research team, highly organized with significant attention to details.
• Proficiency in lab scale manufacturing of LNPs including NanoAssemblr or inline mixing.
• Proficiency in formulation analytics (DLS, zeta potential, UV-Vis and fluorescence spectrophotometry)
• Experience with handling of RNA as well as familiarity with RNA-related analytics (e.g., RiboGreen assay, gel electrophoresis, etc.).
• Knowledge of nucleic acid chemistry and biology

Preferred Qualifications

• Experience with analytical techniques such HPLC, Maldi-TOF MS, LC-MS, NMR
• Experience with bioprocess engineering principles, process modeling and Design of Experiment (DoE) statistical tools.
• Nice to have: Prior experience with extra-hepatic delivery of LNPs or other delivery systems.

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy

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